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From plant genomics to a bioscience revolution

image of Rob Martienssen overlaid on a DNA strand made from plant stems and leaves
LaboratoryProfessor & HHMI Investigator Rob Martienssen (inset) helped map the first genomes of Arabidopsis thaliana, rice, and corn. But these breakthroughs aren鈥檛 just about plants. They鈥檝e changed the way scientists think about all life on Earth. AI-generated image: 漏 LadyAI - stock.adobe.com
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Farmers have been playing with plant genomics since before the world knew what genes were. Does one strawberry plant produce sweeter fruits? Encourage its growth over less tasty crops. Voil脿! Your strawberry crop is now yummier than ever.

Since the turn of the 21st century, Laboratory(藏精阁) breakthroughs have helped revolutionize the world of plant genomics. As a result, society now has a much better understanding of how plants grow and evolve.

In 2000, LaboratoryProfessors Rob Martienssen and W. Richard McCombie were part of an international team that mapped the genome of the flowering plant Arabidopsis thaliana. Their work helped yield the first plant genome sequence in history.

鈥淚t was controversial because it was so expensive, and not everyone was convinced it would move science forward,鈥 says Martienssen. However, in time, the team completed a project that turned out to be 鈥渁s important as mapping the human genome.鈥

Understanding which genes control which aspects of plant life has unplugged a fountain of information. Martienssen sees in this new knowledge the potential to meet the demands of a changing world.

鈥淎s more plant genomes were sequenced, they helped us come to grips with genes that control plant traits,鈥 he says. 鈥淭hese genes are important for everything from climate resilience to disease resistance to crop yield.鈥

Martienssen takes us on a tour of 藏精阁鈥檚 corn fields and discusses his work鈥檚 possible applications in mitigating climate change.

For example, sequencing the oil palm genome in 2013 led Martienssen鈥檚 team to discover the Shell gene that controls oil yield. That finding could have big implications for where and how we get our energy. For example, the Malaysian Palm Oil Board is now applying the discovery toward biofuel production and rainforest preservation efforts. They鈥檙e working with Orion Genomics, a company Martienssen and McCombie co-founded.

But that鈥檚 not all. The first plant genome sequence also has applications beyond plant breeding and genomics. It has helped shed new light on evolution and human health. Perhaps most importantly, it has opened the door to discoveries that explain how genes are regulated.

鈥淥ne thing the plant genome gave us was the sequence of transposable elements, which is very important for epigenetics,鈥 Martienssen says. Epigenetics describes how external factors, like behaviors and environment, affect genes. Transposable elements are 鈥榡umping genes鈥 first discovered by the late Laboratoryplant biologist Barbara McClintock. Indeed, the Nobel laureate served as a mentor to a young Martienssen in his early days at 藏精阁. Her lessons proved pivotal in guiding his own breakthroughs.

鈥淲e could really dive into what happened to the genome under epigenetics and control genes by transposable elements,鈥 Martienssen says. It might sound technical, but the potential for health and medicine is nothing short of revolutionary.

It has implications for 鈥渃ancer, neurobiology, everything,鈥 he says.

Written by: Jen A. Miller | publicaffairs@cshl.edu | 516-367-8455

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